ASSOCIATION OF ATG16L1 T300A GENETIC VARIANT WITH H. PYLORI AND NONE H. PYLORI ATROPHIC GASTRITIS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 14, Issue 1, March 2016, Pages 75-79 | ||
| Author | ||
| Haider F. Ghazi | ||
| Abstract | ||
| Background: Helicobacter pylori persistence may develop atrophic gastritis, gastric ulcer or cancer. Objectives:To determine the association between the presence of autophagy related gene 16 like 1 and thrionin 300 alanine mutation and H. pylori infection among atrophic gastritis patients. Methods:Gastric biopsy was taken from eighty patients and tested for urease, and blood samples were taken for serum separation for detection of Anti-H. pylori IgG by ELISA and DNA extraction from whole blood were used for sequence specific primer – polymerase chain reaction for autophagy related gene 16 like 1 and thrionin 300 alanine mutation allelic discrimination. Results:Among 40 H. pylori positive cases, the carriers of mutated allele were 62.5% compared with 36.25% in H. pylori negative cases (p = < 0.001, OR = 1.72, CI = 1.23-2.42). Conclusions:Among Iraqi atrophic gastritis, there is an association between H. pylori infection and mutated autophagy related gene 16 like 1 and thrionin 300 alanine mutation allele. Thrionin 300 alanine may confer higher risk for infection with H. pylori. Key words: Autophagy, H. pylori, atrophic gastritis. | ||
| Keywords | ||
| Autophagy; pylori; atrophic gastritis | ||
|
Statistics Article View: 66 PDF Download: 57 |
||