Association Ghrelin Level with Insulin Resistance in Type 2 Diabetes Mellitus Obese Patients | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 13, Issue 1, March 2016, Pages 0-0 | ||
| Authors | ||
| Methak J. H. Al-Jboori; Ali Hammod Al-Saadi; Haider Kamel Al-Saadi | ||
| Abstract | ||
| The aim of this study was to investigate the relationship between serum ghrelin concentration with markers of insulin resistance and obesity in type 2 diabetes, Evaluation of the possible association of the obesity in type 2 diabetes and gene polymorphism. The results show that the Levels of ghrelin (mean ± S.E) ghrelin was significantly lower in obese type 2 diabetes compared to control group (p< 0.0001) and Levels of ghrelin did not differ between the 49men and the 59 women. smoking history was significantly. ghrelin showed significant negative correlation with BMI (r= -0.62), Waist/Hip ratio(r = -0.68), SBP (r= -0.53) and DBP(r= -0.43).A significant negative correlation between Ghrelin level and FBG (r= -0.55), HbA1c (r= -0.60), Insulin (r= -0.44) andinsulin resistance index (HOMAIR HOMA-IR(r= -0.46). There was an inverse correlation between Ghrelin level and cholesterol(r= -0.15), triglycerides(r=-0.38) and VLDL(r= -0.38) respectively, while there is no significant correlation with LDL. As well as there weresignificant positive correlation between Ghrelin level and HDL. A significant negative correlation between Ghrelin level and Syctolic bloodpressure and diastolic blood pressure (r= -0.53 andr=-0.43) was observed in the obese type 2 diabetes groups. | ||
| Keywords | ||
| Key Words; Diabetes Mellitus; Obese | ||
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