Assessment of apoB and apoA-I serum levels associated with Acute Coronary Syndrome (ACS) in Babylon province | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 13, Issue 1, March 2016, Pages 0-0 | ||
| Authors | ||
| Hayder Hashim Al-Shalah; Oday Jassim Al-Salihi; Sana Abdul-Jabbar Ali | ||
| Abstract | ||
| Acute coronary syndromes (ACS), is a term that encompasses both unstable angina and myocardial infarction (MI) with or without ST-segment elevation.It is a life-threatening disorder that remain a source of high morbidity and mortality despite advances in treatment. Risk assessment done by using risk factors and risk markers. In the present study assessment of apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) done to recognize their roles as risk biomarkers.Acase control study enrolled 160 subjects; 80 patients diagnosed as ACS patients by expert physicians and 80 controls (non-ACS) subjects. Serum levels of apoB and apoA-I was measured by using ELISA technique. The results were expressed as qi-square categorical statistics. A P value of < 0.05 was considered to be statistically significant. A concentration of apoB>1.3g/L in female and >1.5g/L in male appeared to be eleven times risky for ACS than lower levels (OR=11.2).ApoA-I showed non-significant variation between patients and controls (p>0.05). Subjects having apoB/A-I ratio between (0.6-o.79) as a female and (0.7-0.89) as a male are two times risky to get ACS than controls (OR=2.3).Concluded that apoB is a strong predictor of ACS, abnormal low apoA-I serun level does not contribute to the risk stratification of ACS in the presence of high apoB serum level, and the apo-ratio is the strongest of all lipid-related variables and is thus the best summarizing risk variable. | ||
| Keywords | ||
| ACS; apoB; apoA; ratio; Biomarker | ||
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