Histopathological changes of male reproductive organs treated with oral administration of indomethacin in male rat | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 7, Issue 2, December 2014, Pages 39-45 | ||
| Authors | ||
| S. I. Sabeeh; R. A. Al-Naimi; E. H. Yousuf | ||
| Abstract | ||
| The present study was undertaken to make information about the toxicopathological effects of different doses of indomethacin on male rats' genital organs. The experiment was done on sixty male rats aged (8 weeks) and weighing (170-230 gm), they were divided equally into 4 groups: Group1: Rats served as control (C) and received distilled water for 2 months. Group 2: Rats received by gavage indomethacin diluted in distilled water at 1 mg/kg/B.W/day for 2 months. Group 3: Rats received by gavage indomethacin diluted in distilled water at 2 mg /kg /B.W/day for 2 months. Group4: Rats received by gavage indomethacin diluted in distilled water at 3 mg /kg /B.W/day for 2 months. At the end of experiment scarification (every 30 and 60 days) of the rats has been done. Specimens from testes and epididymis were excised for histopathological examination. The results showed that the pathological changes were dose and time dependent. It was concluded from the study that prolonged use of indomethacin is harmful to the genital organs | ||
| Keywords | ||
| male rat; Histopathological changes | ||
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