Evaluation of Some Serum Adipokines and Oxidized Low Density Lipoprotein Before and After Methotrexate Treatment in Patients with Chronic Plaque Psoriasis (A Case-Control Study) | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 12, Issue 4, December 2015, Pages 0-0 | ||
| Authors | ||
| Mohammed Kadhim Alhattab; Haider Abd Jabbar Alammar; Munaf Salih Daoud | ||
| Abstract | ||
| Psoriasis is a common inflammatory autoimmune skin disease that affects 2–4% of the world population. T-cells infiltration, interleukins and cytokines including adipocytokines like visfatin, high molecular weight- adiponectin (HMW-adiponectin) and retinol binding protein-4 (RBP-4), together with oxidized low density lipoprotein (ox-LDL) have been implicated in psoriasis pathogenesis. A total of 86 subjects (43 with Psoriasis and 43 healthy controls) were enrolled in this study. Their mean age was (41± 14.37) for patients, and (35.81± 18.66) for the control group. The study conducted in dermatology outpatient clinic in Merjan Teaching Hospital in Al –Hilla City and investigations were done in laboratory units of the hospital through the period from June 2013 to September 2014. The sera obtained from blood were used to determine the level of serum visfatin, HMW-adiponectin, RBP-4 and oxidized-LDL by enzyme-linked immunosorbent assay (ELISA). Assessment of psoriasis disease activity and methotrexate efficacy was done by psoriasis area and severity index (PASI) score. Results of this study showed a significant increase (p<0.05) in serum visfatin, HMW- adiponectin, and oxidized-LDL concentrations, and a significant decrease (p<0.05) in retinol binding protein-4 (RBP-4) concentrations in sera of patients with chronic plaque psoriasis when compared with control group. There was a significant correlation between oxidized-LDL and visfatin, HMW-adiponectin and retinol binding protein-4 (r = 0.81, 0.68, -0.77) (p value < 0.001) respectively . Finally, the impact of systemic methotrexate on above adipocytokines and oxidized-LDL was determined by significant reduction in the levels of visfatin, HMW-adiponectin and ox-LDL and a significant increase in levels of RBP – 4 after treatment and by a significant mean difference in PASI score before and after treatment in psoriatic lesions. Results obtained by this study indicate that some adipocytokines including serum visfatin, HMW–adiponectin and RBP-4 levels, in addition to oxidized-LDL measured in patients with chronic plaque psoriasis were closely associated with disease severity and could be used to assess the successful treatment. To the best of our knowledge, this is the first study in Iraq to evaluate serum levels of these adipokines and Ox – LDL in patients with psoriasis and study the effect of methotrexate treatment on these parameters. | ||
| Keywords | ||
| psoriasis; Adiponectin; Visfatin; Rbp; LDL; Methotrexate | ||
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