Acute Toxo-Histopathological study to determining the Median lethal concentration for carbon tetrachloride in liver of common carp (Cyprinus carpio) in Iraq | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 6, Issue 2, December 2013, Pages 1-10 | ||
| Authors | ||
| M. T. Kukez; B. I. Mustafa | ||
| Abstract | ||
| The aims of study to determin the Median Lethal concentration measurement (LC50) of common carp (Cyprinus carpio) in Iraq. Also to estimate the level of Aspartate Amino Transaminase (AST) and Alanine Amino Transaminase (ALT) at (3, 7 and 14) day, fish behavior and histopathological changes were reported in liver of acute toxic concentration of common carp (Cyprinus carpio). Use 64 fish (common carp) weight (150-250) g were divided into 2 experimental 1st experiment (probit study) include 8 fish (common carp) distributed into 4 sub groups each groups included 2 fish (common carp) were exposed to (2, 4, 6 and 8) ppm ccl4 for 72 h. 2nd experimental (probit study) included 56 common carp divided into 7 equal group each group consist of 8 fish (1st group control) and the other group exposed to (3.5, 3.6, 3.7, 3.8, 3.9 and 4) ppm ccl4 respectively. Result showed that included fish behavioral changes, C.N.S sings appeared after exposure to various concentration characterized by increase swimming activity, hyper activity and increase movement. LC50 resulted in common carp 3.758 ppm with significant increase (p≤0.05) in AST and ALT enzyme in blood serum. Liver histopathological examination showed in acute treated group necrosis with inflammatory cells infiltration mostly neutrophils and lymphocytes, congestion of liver blood with extensive hemorrhage. We can concluded from this study there are highly toxicity effect of CCl4 in common carp that brought in Iraq which leads to increase of liver Enzymes (AST and ALT) as well as hepatic tissue damages | ||
| Keywords | ||
| common carp; Toxo; histopathological | ||
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