THE ROLE OF TUMOR NECROSIS FACTOR Α (TNF-Α) AND INTRACELLULAR ADHESION MOLECULES-1 (ICAM-1) IN ATHEROSCLEROTIC CORONARY HEART DISEASE | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 13, Issue 2, August 2015, Pages 173-177 | ||
| Authors | ||
| Wurood A.S. Kadhum; Nidhal M. Abdul-Muhaymen; Qudus W. Jamal | ||
| Abstract | ||
| Background:Tumor necrosis factor-α elaborated soon after myocardial ischemic injury. The intracellular adhesion molecule-1 is required for polymorphonuclear emigration, the primary cause of inflammatory tissue damage due to ischemia-reperfusion. Objective:Detect the serum level of tumor necrosis factor-α and to look for the percentage of expression of intracellular adhesion molecule-1 in atherosclerotic coronary heart disease. Methods:Fifty patients (40 males and 10 females) were enrolled in this study with age range (42-80) years, and fifteen, age and sex matched, apparently healthy individuals. The patients group was further classified into acute and chronic cases. Blood sample was taken from each subject and divided into 2 parts. One part used for lymphocyte separation by using immunocytochmistry to detect intracellular adhesion molecule-1 and the other one for serum separation by using ELISA technique to detect tumor necrosis alpha-α. Results:Significant difference in the concentrations of tumor necrosis factor-α was found between patients and control groups and it was elevated in acute cases compared to chronic cases. Similarly, intracellular adhesion molecule-1 was elevated in patients compared o control groups and more in acute than chronic cases. Conclusions:TNF-α is an important marker that acts on coronary arteries which may contribute to the development of congestive heart disease. Elevation of intracellular adhesion molecule-1 level correlates well with the development of acute events in the disease. Keywords:Atherosclerotic coronary heart disease, TNF-α, ICAM-1, ELISA, immunocytochemistry technique. | ||
| Keywords | ||
| Atherosclerotic coronary heart disease; TNF; ICAM; ELISA; immunocytochemistry technique | ||
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