Prevalence of Matrix metalloproteinase-9 in Breast Cancer As a Marker of Prognosis | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 13, Issue 2, August 2014, Pages 266-272 | ||
| Authors | ||
| Ayda M.Majeed; Noor H.Ismil; Zaina F.Ashoor; Wasan A.Bakir | ||
| Abstract | ||
| Matrix metalloproteinase-9 (MMP-9) is regarded as important for degradation of the basement membrane and extracellular matrix during cancer invasion and other tissue-remodeling events. the aim of this study is to investigate and compare the expression of MMP-9 in human breast adenocarcinoma with fibroadenoma. In this study we evaluate the prognostic value of MMP-9, by in situ hybridization staining in a series of 30 breast cancer tissues. Both mean percentage of MMP-9 MRNA and scoring of it,s expression in normal and cancer, showing an increased expression of MMP-9 was significantly high in tumor compared with control samples, with extensive score among breast cancer tissues. This study shows that MMP-9 expression in breast cancer is associated with better prognosis. | ||
| Keywords | ||
| MMP; Breast cancer; fibroadenoma; Adenocarcinoma | ||
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