Preparation and identification of oxidatin derivaties for Salts and acids of bile for medical uses | ||
| Baghdad Science Journal | ||
| Article 1, Volume 1, Issue 1, June 2004, Pages 1-7 | ||
| Authors | ||
| Salma A. R. Abbas; Anis M. Al-Rawi; Saadi M. Daher | ||
| Abstract | ||
| Astudy for prearated Oxidized Derives of bile acid And Salts for Medical purposes Two methods were used to oxidize some derivation of cholic acid and deoxy cholic acid nsing potassinm in dichromate in acetic acid and chromic trioxide The following compounds were purified: 1. Mchyl(^7-,12-)trihydroxy cholan-24-oate (1). 2. Methyl(3-,12-)dihydroxy cholan-24-oate (11). 3. Methyl(3-,7-)diacetate.l2-hydroxycholan-24-oate (111). 4. Methyl 3-acetate,12-hydroxycholan-24-oate (IV). 5. 3H^roxy,(7-,13)diketocholan-24-oic acid (V). 6. 3-Hydroxy,12-keto cholan-24-oic acid (VI). 7. Methyl 3- h}'droxy(7-, 12-)diketocholan-24-oatc (VII). 8. Methyl 3-hydroxy,12-ketocholan-24-oate (VIII). 9. (3^,13)^iketocholan-24-oic acid (1^). The purified prepared compounds were identified through different methods of identification i.e, I.R, UV-vi^ble-spectroscopy in addition to (coloured tests) Calculation of the sum of OH groups. TLC techniques were also used to test the purity and the speed ofthe rate of flow (RF). | ||
|
Statistics Article View: 13 PDF Download: 9 |
||