Haematological study of beta thalassemia in holy Kerbala Governorate | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 4, December 2014, Pages 195-202 PDF (0 K) | ||
| Abstract | ||
| The importance of the present study was in the haematological and biochemical evaluation of haemoglobin in beta - thalassemia patients in holy Kerbala Governorate , A total of 36 blood samples were collected from beta - thalassemia major patients and 20 samples from beta - thalassemia intermedia patients from Al-Hussein medical city in Kerbala and compared with 20 samples from apparently healthy control group. The blood groups for all studied samples were determined , and the correlation between the blood groups and the phenotypic pattern of the disease was studied . The results revealed that there was significant statistical correlation between beta - thalassemia major and blood groups B&O; and between beta- thalassemia intermedia & blood group A. The complete blood picture for all samples were determined including (RBC count ,WBC count ,blood platelet count, hematocrit (HCT), Mean cell volume(MCV) , Mean cell hemoglobin(MCH) and Mean cell hemoglobin concentration (MCHC) . The results revealed significant statistical differences between patients groups and apparently healthy individuals for all studied parameters except WBC counts. The concentrations of Hb were determined,and the quantative and qualitative analyses of Hb using Hb electrophoresis were adopted to determine the Hb types (HbA, HbA2 and HbF) and their percentages,the results showed significant differences between studied groups for these three types of haemoglobin.In thalassemia major HbF (76.06% ± 25.70),HbA (23.55%±19.83) and HbA2 (3.90% ± 2.98) Whereas the results in thalassemia intermedia showed the percentage of HbF (7.16% ± 1.52), HbA(56.58% ± 17.9) and HbA2(7.45% ± 5.48) | ||
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