Effect of ethanol extract of leave Vinca rosea plant on some physiological parameter in males albino rat induct diabetes | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 4, December 2014, Pages 8-15 PDF (0 K) | ||
| Abstract | ||
| Seventy five white male rats were used in the present study , these animals randomly divided into five groups (15 rat for each) , first group G1 was recive physiological saline daily for two months , while animal of the second group G2 had induced diabetes mellitus by intraperitoneal injection of 150 mg/kg/Bw of alloxan and considered as control positive group . Animal of third group were subjected to same protocole used in G2 in addition to that they were treated with 150 mg/kg/Bw of ethanolic extract of Vinca rosea after month of induction of diabetes mellitus for 30 days. Animals of fourth G4 and fifth G5 groups were apllied to the same treatment that used in the animals of G3 except that the dose of Vinca rosea were 200 and 250 mg/kg/Bw respectivly. Blood samples were collected from all groups of experiment before the induction of diabetes , a month after the induction of diabetes , and after a month of dosing ethanol extract of Vinca rosea ,the study of parameters which included, measurement Blood Hemoglobin(Hb) , Red blood cells count (R.B.C) , White blood cells count (W.B.C.), and Packed cell volum (PCV),the results of present study showed a significant decrease (p<0.05) in Hb levels, R.B.C count and PCV level and significant increase (p<0.05) in W.B.C count in all diabetes group compared with intact control group . There a significant increase (p<0.05) in the Hb level, R.B.C count and PCV level, and significant decrease (p<0.05) in the W.B.C count in treatment with ethanol leaves Vinca rosea compared to the infected control group | ||
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