The effect activity of phenolic and alkaloids compounds extracts of Punica granatum and praziquantel drug on the growth and development of hydatid cyst for Echinococcus granulosus In vivo . | ||
| Euphrates Journal of Agriculture Science | ||
| Article 1, Volume 6, Issue 2, April 2014, Pages 195-212 | ||
| Abstract | ||
| Abstract : This study was designed to evaluate the effect of secondary compound extracts (phenolic and alkaloid) of Punica granatum fruit peel on the growth and development of hydatid cysts of Echinococcus granulosus in white mice Balb/c and comparative its therapeutic effect with praziquantel drug effect. Then determined the therapeutic dose of crude phenolic compounds which were 79 mg/kg and 80 mg/kg therapeutic dose in crude alkaloid compounds , the therapeutic dose of praziquantel drug was 10mg/kg , These extracts and praziquantel drug which used for oral administration in mice for one month and one dosage as average daily after protoscolices infected and left for four months , The crude phenolic compounds were reduced efficiently the weight , number and diameter of hydatid cysts in infected mice which were 0.0052 gm , 0.66 and 1.55 mm , respectively , The crude phenolic compounds were more effective in reduce the weigh of liver , spleen and lung (2.15, 0.21and 0.22) gm , respectively, comparison with positive control group not treated . The AST and ALT liver enzymes were estimation , Praziquantel drug was efficiently in decrease enzymes level AST and ALT into the normal level which was (170 and 30.76) IU/ml , respectively . | ||
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